Affibody tar ännu ett steg i utvecklingen av läkemedel i egen regi

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Affibody and Inmagene announce IND Clearance for izokibep (ABY-035) for the treatment of Non-infectious Non-anterior Uveitis. “Our Phase 2 AFFIRM-35 study with ABY-035 has now reached the stage where we are starting to see the first results”, said David Bejker, CEO of Affibody. A Study to Investigate Efficacy, Tolerability and Safety of ABY-035 in Patients With Active Psoriatic Arthritis Sponsorer. Ledande sponsor: Affibody. Affibody har beslutat att gå vidare med utvecklingen av företagets egna psoriasisprogram, ABY-035, genom att initiera fas två i den kliniska studien. ett strategiskt partnerskap med kinesiska Inmagene Biopharmaceuticals inom utvecklingen och kommersialiseringen av ABY-035, en bispe. Svenska bioteknikbolaget Affibody som ägs av Investors av den biologiska läkemedelskandidaten ABY-035, som för närvarande är i en tysk Affibody and Inmagene announce IND Clearance for Izokibep (ABY-035) for the treatment of Ankylosing Spondylitis 2021 02 10; 08:30:00.

Smaller high-affinity scaffold proteins are attractive non-Fc containing alternatives to antibodies. A previous study indicated that anti-HER3 affibody Inmagene and Affibody have formed a strategic partnership to develop and commercialize izokebep (IMG-020 or ABY-035), a bispecific fusion protein targeting Interleukin-17A, for multiple auto-immune indications worldwide. Solna, Sweden, June 15, 2020. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced positive top-line data from its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with moderate-to-severe psoriasis (“AFFIRM-35”). Solna, Sweden, July 16, 2019. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company developing a pipeline of innovative drug projects, today announced the completion of the planned 12 week interim analysis in the Company’s Phase 2 proof-of-concept study of its bispecific molecule ABY-035 for moderate-to-severe psoriasis (“AFFIRM-35”).

ABY-039. Antibody mediated autoimmune diseases. Immunology.

Svensk Patenttidning 200550 - PRV

Affibody AB (“Affibody”) today announced that it has decided to initiate Phase II development with ABY-035, which is the company’s proprietary psoriasis program. DUBLIN – Affibody AB is getting $10 million up front and up to $215.5 million in regulatory and sales milestones from a licensing deal with Inmagene Biopharmaceuticals Co. Ltd., in which the latter firm gains commercial rights to its interleukin-17 inhibitor ABY-035 in China, Hong Kong, Taiwan, Macau and South Korea. Solna, Sweden, February 20, 2019. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company developing a pipeline of innovative drug projects, today announced the completion of enrollment in the Company’s Phase 2 proof-of-concept study of ABY-035 for moderate-to-severe psoriasis (“AFFIRM-35”).

Senior Biostatistician - Affibody - Haeger & Carlsson

Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced the initiation of its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with psoriatic arthritis (PsA). ABY-035 is a novel bispecific agent, potently targeting both subunits of IL-17A as well as albumin, which has been specifically designed to utilize the strengths of Affibody’s technology platform to create a very small protein drug (18 kDa, an eighth of the size of an antibody) with very high apparent affinity to IL-17A (KD ~300fM) and antibody-like half-life due to the strong (KD ~50pM) binding affinity to serum albumin.

ABY-035 / AFB-035 (Affibody). 6.7. MP0250 ( Molecular Partners). 6.8. PRS-080 (Pieris Pharmaceuticals). 7. Affibody is a Swedish biotech company focused on developing products for therapy, diagnostic imaging, and other applications.
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(a) and the molecule wa s named ABY-035 and ha s entered clinic al. developmen t. Recently, the he althy voluntee r dose escalatio n. 2019-02-01 Affibody Enters into Agreement with 3P Biopharmaceuticals for Production of ABY-035 Pressmeddelanden • Maj 27, 2019 11:06 CEST. Solna, Sweden, May 27, 2019. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced an agreement with 3P Biopharmaceuticals (“3P”) covering process development and GMP manufacturing of Affibody’s ABY-035 drug. On Friday, the company gained commercialization rights to protein-based IL-17A inhibitor IMG-020 (ABY-035) from Affibody AB in mainland China, Taiwan, Hong Kong, Macau and South Korea in exchange for a $10 million upfront payment and up to $215.5 million in milestones plus royalties.

Affibody AB (“Affibody”), a clinical stage biopharmaceutical company developing a pipeline of innovative drug projects, today announced the completion of the planned 12 week interim analysis in the Company’s Phase 2 proof-of-concept study of its bispecific Affibody, a clinical stage biopharmaceutical company, today announced positive top-line data from its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with moderate-to-severe psoriasis (“AFFIRM-35”). Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (“Inmagene”) today announced that the U.S. FDA has cleared the novel interleukin-17 (IL-17) blocker izokibep (ABY-035) to proceed Solna, Sweden, November 10, 2020. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced the initiation of its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with psoriatic arthritis (PsA). Partners eye additional applications in autoimmune diseases during 2021. SAN DIEGO, CA, USA; SHANGHAI, China, and SOLNA, Sweden I February 10, 2021 I Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (“Inmagene”) today announced that the U.S. FDA has cleared izokibep (ABY-035) to proceed to Phase 2 clinical development in Ankylosing Spondylitis (AS), a subset of Axial 2020-05-19 Affibody will be responsible for the manufacturing and supply of ABY-035 for development and commercialization worldwide and is not precluded from additional collaboration and licensing agreements in territories not covered by this agreement. About ABY-035. Currently in Phase 2 development, ABY-035 is an innovative fusion protein targeting IL-17.
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Affibody: ClinicalTrials.gov Identifier: NCT03591887 Other Study ID Numbers: ABY-035-002 2017-001615-36 ( EudraCT Number ) First Posted: July 19, 2018 Key Record Dates: Last Update Posted: July 10, 2020 Last Verified: July 2020 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Affibody secures production capacity for ABY-035. An important next step in the advancement of ABY-035 to late stage clinical development. “Ensuring large scale high quality production of our ABY-035 drug is a natural next step in our evolution as a company with the ambition to have development, manufacturing, and commercialization expertise”, said David Bejker, CEO of Affibody. Partners will continue to file INDs in additional applications in autoimmune diseases during 2021. SAN DIEGO, CA, USA; SHANGHAI, China, and SOLNA, Sweden I March 9, 2021 I Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (“Inmagene”) today announced that the U.S. FDA has cleared the novel interleukin-17 (IL-17) blocker izokibep (ABY-035) to proceed to Phase 2 clinical Affibody announces that it has decided to initiate Phase II development with ABY-035, which is the company’s proprietary psoriasis program. “This Affibody molecule, ABY-035, has been specifically designed to capture the unique aspects of the Affibody technology. It is a bi-specific construct with extraordinary affinity and confirmed antibody-like half-life.

Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer2020Ingår i: EJNMMI Research, ISSN I maj-20 licensierade onoterade Affibody också ut ABY-035 (som visat goda data under fas 2 i psoriasis) för auto-immuna sjukdomar till Comparative evaluation of anti-HER2 affibody molecules labeled with 68Ga Site-specific radiometal labeling and improved biodistribution using ABY-027, Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding imaging using a picomolar affinity HER2 binding affibody molecule2006Ingår agreement with Affibody. Affibody has also announced positive data from its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in ABY-057. Alzheimer's disease. CNS. ##. Affibody. ABY-039.
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Klinisk prövning på Psoriatic Arthritis: ABY-035, Placebo

Affibody AB | 3 455 följare på LinkedIn.

Svensk Patenttidning 200550 - PRV

The Company specializes in the discovery of a novel class of antibody mimetics that provide biodistribution affibody is a clinical stage swedish biotech company focused on developing next generation biopharmaceuticals based on its unique proprietary technology Nov 30, 2014 The project aims to provide documentation necessary to start GMP manufacturing of the Affibody®-based RIT and subsequently start clinical trials We supported the bioanalysis for ABY-035, a small protein drug of only 19 Affibody's technology platform to create an IL-17-specific ligand trap with a superior.

Solna, Sweden, July 16, 2019.